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Warm Substances in Protease Inhibitor Assortment

proteasome

MG-132  CAS No. 133407-82-6

MG-132  is definitely an inhibitor of proteasome with IC50 of 100 nM in a portable-absolutely free assay, and likewise inhibits calpain with IC50 of 1.2 μM.

20S proteasome

Bortezomib CAS No. 179324-69-7

Bortezomib (PS-341) is really a effective 20S proteasome inhibitor with Ki of .6 nM inside the portable-cost-free assay.

proteasome

Carfilzomib CAS No. 868540-17-4

Carfilzomib (PR-171) is unquestionably an long-lasting proteasome inhibitor with IC50 of <5 nM in ANBL-6 tissues, demonstrated preferential in vitro inhibitory efficiency against the ChT-L exercising inside of the β5 subunit, but no less than influence on the PGPH and T-L activities.

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