Warm-promoting inhibitors

TargetMol’s popular-marketing inhibitors for your selection.

1. Vemurafenib

Vemurafenib (PLX4032, RG7204) is actually a novel and powerful inhibitor of B-RafV600E with IC50 of 31 nM.

2. Olaparib

Olaparib (AZD2281, KU0059436) is really a particular inhibitor of PARP1/2 with IC50 of 5 nM/1 nM, 300-times less effective against tankyrase-1. Phase 3.

3. . Rapamycin

. Rapamycin (Sirolimus, AY-22989, WY-090217) is actually a distinct mTOR inhibitor with IC50 of ~.1 nM.

4. Ibrutinib (PCI-32765)

Ibrutinib (PCI-32765) is actually a strong and highly particular Brutons tyrosine kinase (Btk) inhibitor with IC50 of .5 nM, modestly effective to Bmx, CSK, FGR, BRK, HCK, much less potent to EGFR, Yes, ErbB2, JAK3, and many others.

5. Trametinib

Trametinib (GSK1120212) is a highly certain and strong MEK1/2 inhibitor with IC50 of .92 nM/1.8 nM, no inhibition from the kinase actions of c-Raf, B-Raf, ERK1/2.

TargetMol is headquartered in Boston, Massachusetts. Our central goods are molecular libraries and inhibitors, which include over 4000 bioactive ingredients. Our compounds can be used for mobile transmission transduction experiments, mobile inducing experiments, medication repositioning, and optimistic control tests.

Target Molecule Corp.

Deal with: One Boston Place, Suite 2600, Boston, Massachusetts, 02108

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