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Cozy-providing Inhibitors

Rock and roll and roll and roll inhibitor

Y-27632 dihydrochloride

Y-27632 dihydrochloride is truly a fussy ROCK1 (p160ROCK) inhibitor with Ki of 140 nM, shows>200-break down selectivity over other kinases, which include PKC, camping outdoors-dependent health proteins kinase, MLCK and PAK.

Related Items: Thiazovivin, Fasudil (HA-1077) HCl

GSK-3 inhibitor

CHIR-99021

CHIR-99021 (CT99021) HCl is hydrochloride of CHIR-99021, which is a GSK-3α/β inhibitor with IC50 of 10 nM/6.7 nM opportunity to separate GSK-3 and its dearest homologs Cdc2 and ERK2.

Related Items: SB216763 , CHIR-98014

Proteasome Inhibitor

MG-132

MG-132 is undoubtedly an inhibitor of proteasome with IC50 of 100 nM, in addition to inhibits calpain with IC50 of 1.2 μM.

Connected Products: Carfilzomib (PR-171) , ONX-0914 (PR-957)

HDAC Inhibitor

Romidepsin (FK228, Depsipeptide)

Romidepsin (FK228, depsipeptide) is definitely a powerful HDAC1 and HDAC2 inhibitor with IC50 of 36 nM and 47 nM, respectively.

Relevant Goods: Entinostat (MS-275) , Trichostatin A (TSA)

Akt Inhibitor

MK-2206 2HCl

MK-2206 2HCl may well be a highly fussy inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM, respectively no inhibitory workouts against 250 other healthy needed protein kinases noticed. Cycle 2.

Appropriate Products: AZD5363 , GDC-0068

Raf Inhibitor

Vemurafenib

Vemurafenib (PLX4032, RG7204) is in reality a exclusive and solid inhibitor of B-RafV600E with IC50 of 31 nM.

Related Issues: Sorafenib Tosylate , PLX-4720

Item Catalog

Aspect Choice

32 forms of element libraries for leading throughput affirmation and articles affirmation.

Examine Locations

Proteases/Proteasome

Chromatin/Epigenetic

JAK/STAT Signaling

Tyrosine Kinase/Adaptors

PI3K/Akt/mTOR Signaling

MAPK Signaling

Apotosis

Ubiquitination

Angiogenesis

Immunology/Irritation

DNA Issues/DNA Upkeep

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